The Perixx Periduo-605 wireless ergonomic split keyboard and mouse often stop working due to battery, USB, or driver issues. Simple fixes like replacing batteries, reconnecting the receiver, and updating drivers usually solve the problem.
The Perixx Periduo-605 wireless ergonomic split keyboard and mouse combo is popular for its comfort and efficiency, especially for people who type for long hours. It features a split design that helps reduce wrist strain and provides a natural typing position.
However, like any wireless device, users sometimes face issues where the keyboard or mouse stops working. These problems can be frustrating, but most are fixable with simple troubleshooting steps.
In this guide, we’ll explore why your Perixx Periduo-605 may not work, how to fix common problems, and tips to prevent these issues in the future.
Overview of the Perixx Periduo-605
The Perixx Periduo-605 is a wireless ergonomic combo designed for comfort and productivity. Its key features include:
- Split Keyboard Design: Supports natural hand positioning.
- Integrated Palm Rest: Reduces strain during typing.
- Wireless 2.4GHz Connection: Ensures stable connectivity without clutter.
- Compact Mouse: Matches ergonomic principles for hand comfort.
- Plug-and-Play Setup: No extra software needed for basic use.
Despite its great features, connectivity and performance issues may arise over time, leading to the keyboard or mouse not functioning properly.
Common Reasons Why the Perixx Periduo-605 Stops Working

Before diving into fixes, it’s important to understand why the device may fail. Here are the most common causes:
1. Battery-Related Issues
- Weak or dead batteries are a leading cause of connection failure.
- Incorrect battery placement can prevent power from reaching the device.
2. USB Receiver Problems
- A loose or damaged USB receiver may not connect properly.
- Using the receiver in a faulty USB port can also cause malfunctions.
3. Driver Conflicts
- Outdated or corrupted drivers in Windows or macOS may block communication.
4. Wireless Interference
- Nearby wireless devices or metal objects can disrupt the 2.4GHz signal.
5. Hardware Defects
- Physical damage to the keyboard, mouse, or receiver can prevent operation.
6. Sleep or Power Saving Mode
- The device may automatically enter sleep mode to conserve power, causing temporary unresponsiveness.
Step-by-Step Fixes for Perixx Periduo-605 Keyboard and Mouse
Step 1: Check the Batteries
- Remove the batteries from both the keyboard and mouse.
- Insert fresh alkaline batteries (AA or AAA depending on the model).
- Ensure proper orientation (+/- alignment).
- Turn on the devices and test them.
Tip: Rechargeable batteries often have lower voltage and may not work as reliably as standard alkaline batteries.
Step 2: Reconnect the USB Receiver
- Remove the USB receiver and reinsert it into a different USB port.
- Prefer using USB 2.0 ports instead of USB 3.0, as compatibility is usually better.
- Restart your computer to refresh the connection.
Step 3: Update or Reinstall Drivers
For Windows users:
- Open Device Manager.
- Find the keyboard and mouse under Human Interface Devices or Keyboards.
- Right-click and choose Update Driver.
- If issues persist, uninstall the device and restart your PC — it will reinstall automatically.
For macOS users:
- Ensure your system is updated to the latest macOS version.
- Remove the device from Bluetooth or input settings and reconnect via the USB dongle.
Step 4: Test for Wireless Interference
- Move other wireless devices (Wi-Fi routers, cordless phones, etc.) away from the keyboard and mouse.
- Use the combo closer to the USB receiver to reduce signal loss.
Step 5: Reset the Devices
Some Perixx models allow resetting:
- Turn off the keyboard and mouse.
- Hold specific keys (often Esc + K or Fn + Esc) while turning it back on.
- Refer to the user manual for exact reset instructions.
Step 6: Check for Hardware Damage
- Inspect the USB receiver for bent pins or cracks.
- Check the battery compartments for corrosion or loose springs.
- If damage is found, contact Perixx support for replacement options.
Specific Fixes for the Keyboard Not Working
- Verify the split layout settings on your OS — sometimes remapping tools interfere.
- Disable Sticky Keys or Filter Keys in Windows accessibility settings.
- Try connecting the keyboard alone (without the mouse) to isolate the issue.
Specific Fixes for the Mouse Not Working
- Clean the mouse sensor and ensure no dust blocks the light.
- Test the mouse on a different surface or mouse pad.
- If clicks are unresponsive, check for physical button damage.
When Both Keyboard and Mouse Stop Working

If both stop working simultaneously:
- The issue is likely with the USB receiver or system compatibility.
- Test the receiver on another computer — if it works there, the issue is software-related on your main system.
- If it doesn’t work anywhere, the receiver may be defective.
Preventing Future Problems
To avoid recurring issues:
- Replace batteries regularly before they completely drain.
- Keep the USB receiver plugged directly into the computer instead of a hub.
- Store the keyboard and mouse away from liquids and extreme heat.
- Periodically clean the keyboard to prevent dust buildup.
- Update your operating system and drivers for smooth compatibility.
Contacting Perixx Support
If troubleshooting fails:
- Visit the Perixx support page for FAQs and manuals.
- Check your warranty (often 1-2 years).
- Contact support with your purchase receipt and product details for replacement or repair options.
Why Choose Perixx Periduo-605 Despite Issues?
Even though occasional malfunctions occur, the Perixx Periduo-605 remains a strong choice for:
- Ergonomic design reducing wrist and shoulder pain.
- Wireless convenience without cables cluttering your desk.
- Affordable price point compared to premium ergonomic brands.
- Reliable performance once properly set up and maintained.
FAQs:
1. Why does my Perixx Periduo-605 keyboard randomly disconnect?
Random disconnections occur due to weak batteries, wireless interference, or loose USB receiver connections. Replacing batteries, using a stable USB port, and avoiding interference from other wireless devices usually resolves this issue.
2. Can I use rechargeable batteries in the Perixx Periduo-605?
Yes, but rechargeable batteries often have lower voltage than standard alkaline batteries. This may cause shorter operation time or random dropouts. Using high-quality alkaline batteries is recommended for consistent performance and fewer connection problems.
3. Does the Perixx Periduo-605 work on macOS without extra drivers?
The Periduo-605 is plug-and-play on macOS, but some special function keys may not work natively. Adjust keyboard settings in macOS preferences or use third-party software to enable full key customization and compatibility.
4. How can I fix lagging mouse movements on the Perixx Periduo-605?
Lagging is usually caused by weak batteries or wireless interference. Replace the batteries, clean the sensor, and use the mouse closer to the USB receiver. Avoid using near Wi-Fi routers or metal objects blocking signals.
5. What should I do if both keyboard and mouse stop responding?
If both stop responding, check the USB receiver first. Test it in another port or device. If it still fails, reinstall drivers or request a replacement receiver from Perixx customer support under warranty.
Conclusion
The Perixx Periduo-605 wireless ergonomic split keyboard and mouse provide excellent comfort and functionality, but connection problems can occur. Most issues stem from basic causes like dead batteries, USB receiver faults, or outdated drivers, which are easy to fix. By replacing batteries, updating drivers, and ensuring proper setup, users can restore performance quickly. If hardware failure is suspected, Perixx’s support team can help with repairs or replacements. With proper maintenance, this combo remains a reliable ergonomic solution for daily use.